2026-03-05Science

Rapamycin, Metformin, or Just NOVOS Core? A Nuanced Guide to Longevity Pharmacology.

Should you take rapamycin or metformin for longevity, or do OTC supplements like NOVOS Core, NMN, and fisetin cover the same ground? A tiered, evidence-based breakdown.

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n1 longevity – Evidence-Based Longevity Science & Health Optimization

n1 longevity is a comprehensive health tracking and longevity science platform. Track biomarkers, run n=1 experiments, and optimize your healthspan with evidence-based protocols.

Blog – Longevity Science & Health Optimization Articles

MaryRuth's Organics: $400M Built on Frequency, Not Just Formulations – How David Ghiyam's Kabbalah practice and MaryRuth's clinical nutrition built a $400M vitamin empire.
Why the Longevity Space Needs a Neutral Validation Layer – The companies producing longevity products shouldn't be the only ones validating them.
SSRIs Don't Work. The Things That Do Are the Same Things That Extend Your Life. – The Venn diagram of 'what actually treats depression' and 'what extends lifespan' is basically a circle.
If Peptides Were Actually Regulated, Which Ones Would Survive? – Every popular peptide ranked by evidence quality, safety profile, and what would survive real FDA scrutiny.
Rapamycin, Metformin, or Just NOVOS Core? – A tiered, evidence-based breakdown of longevity pharmacology.
Every Common Medication Ranked for Longevity – SSRIs, benzos, Adderall, Wellbutrin, Ambien, Ozempic, statins — ranked by longevity trade-offs.
Your Ketamine Clinic Isn't Showing You This Research – Ketamine elevates cortisol via HPA axis disinhibition.
You're Not Supposed to Grow All the Time. The Case for Cycling mTOR. – mTOR is your body's gas pedal — the longevity advantage comes from knowing when to press each one.
Being Healthy Is Beautiful. Clearing Your Skin's Senescent Cells Is a Longevity Strategy. – Clearing senescent skin cells isn't vanity — it's cancer prevention.
Your Skin Is a Longevity Biomarker – Skin aging is a visible readout of systemic inflammation and metabolic health.
Slowing Aging by 1 Year Is Worth $38 Trillion – Population collapse is forcing governments to invest in keeping people alive.
Americans Want to Inject Their Way to Longevity. The Research Says Eat a Vegetable. – Foundational longevity interventions the industry can't monetize.
The White House Eats Organic. You Eat Atrazine. – The pesticide-endocrine disruption connection the longevity community ignores.
Universe 25: What a Mouse Paradise Tells Us About Aesthetic Wellness Culture – Calhoun's mice had unlimited resources. They went extinct anyway.
Men Need Women More Than Women Need Men — Longevity Data – Marriage extends men's lives by up to 17%.
"Not Evaluated": How One FDA Disclaimer Protects Scammers – The FDA's binary framework fails consumers and companies doing real science.
NOVOS Core Just Published Human Clinical Trial Results – A randomized, double-blind trial shows NOVOS Core improved vascular aging markers.
The Carrot Scanner Problem: Why Measuring One Thing Isn't Health Tracking – Samsung put a beta carotene scanner in a smartwatch. But that isn't health tracking.
The Longevity Intervention Landscape – Supplements, prescriptions, therapies, and lifestyle changes — what the evidence says.
The Placebo Effect Proves Manifestation Is Real – Clinical proof that belief changes biology.
The 12 Hallmarks of Aging – From genomic instability to chronic inflammation — what the latest longevity research says.
The Peptide Paradox: Cancel the "Longevity" Influencers – Peptide influencers selling compounds that can grow tumors.
Longevity Supplements: Survivorship Bias and Marketing Vagueness – Why 'clinically studied' deserves more scrutiny.
The Science of Living Longer: Why Optimists Outlive Pessimists – Research shows optimists live 15% longer.
Introducing Health Tracking: Your Complete Wellness Dashboard – Track sleep, exercise, nutrition, and supplements with AI-powered insights.
Micro-Dosing Lithium: The Forgotten Mineral for Mood Stability – How trace lithium in drinking water supports mood stability and longevity.
Neuroplasticity Has Limits: What the Science Actually Shows – The brain is adaptable, but not infinitely.
The Science of Gratitude: Why It Actually Works – Gratitude physically changes your brain structure.
How a Positive Outlook Rewires Your Brain – Breaking free from victim mentality with neuroscience.
The Mind-Body Feedback Loop – Exercise, nutrition, and sleep create the biological foundation for mental change.
Your Social Circle Is Your Frequency – The neuroscience of social contagion and why your closest relationships shape your biology.
Gamma Waves and Meditation: What Tibetan Monks Teach Neuroscience – Buddhist monks show gamma wave activity 700% above baseline.
Your Nervous System Is the Engine of Manifestation – How vagal tone, HRV, and autonomic regulation create behavior change.